More than 35 million people worldwide are living with dementia, and the numbers are expected to double by 2030, according to the World Health Organization. AD is the most common cause of dementia and is incurable.
"The grey matter volume is a key marker of brain health. Larger grey matter volume means a healthier brain. Shrinking volume is seen in Alzheimer's disease," said Cyrus Raji, radiology resident at the University of California in Los Angeles (UCLA), who conducted the study.
Raji and colleagues recently examined how an active lifestyle can influence brain structure.
They studied 876 adults of an average age of 78 years, drawn from the multi-site Cardiovascular Health Study. The patients' conditions ranged from normal cognition to Alzheimer's dementia, according to an UCLA statement.
"We had 20 years of clinical data on this group, including body mass index and lifestyle habits," Raji said. "We drew our patients from four sites across the country, and we were able to assess energy output in the form of kilo-calories per week."
The lifestyle factors examined included recreational sports, gardening and yard work, bicycling, dancing and riding exercise cycle.
"The areas of the brain that benefited from an active lifestyle are the ones that consume the most energy and are very sensitive to damage," Raji added.
"What struck me most about the study results is that it is not one but a combination of lifestyle choices and activities that benefit the brain," Raji said.
"Virtually all of the physical activities examined in this study are some variation of aerobic physical activity, which we know from other work can improve cerebral blood flow and strengthen neuronal (brain cell) connections," he said.
Researchers used magnetic resonance imaging (MRI) and a technique called voxel-based morphometry, "an advanced method that allows a computer to analyze an MR image and build a mathematical model that helps us understand the relationship between active lifestyle and gray matter volume," said Raji.
These findings were presented at the annual meeting of the Radiological Society of North America (RSNA).
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